Chemical & Pharmaceutical

Sealing products used in the chemical and pharmaceutical industries are key components in ensuring that manufacturing processes are safe, efficient and meet stringent hygiene standards. These seals need to be chemically resistant, temperature resistant, abrasion resistant, non-toxic and non-contaminating in order to cope with complex process conditions and stringent hygiene requirements.

Seals materials

Fluoroelastomer (FKM/Viton): excellent chemical resistance and high temperature resistance, suitable for most chemicals and high temperature environments.

Silicone Rubber (VMQ): Good heat resistance, cold resistance and electrical insulation, suitable for food grade and pharmaceutical grade applications.

Nitrile Rubber (NBR): Good oil and abrasion resistance for petroleum-based chemicals and lubricants.

Ethylene propylene diene diene rubber (EPDM): good weather and ozone resistance, suitable for water treatment and general chemicals.

Polytetrafluoroethylene (PTFE): excellent chemical resistance and low coefficient of friction, suitable for strong corrosive media and high temperature environments.

Polyether ether ketone (PEEK): excellent chemical resistance, high temperature resistance and mechanical strength, suitable for high-end applications.

Seals types

O-Ring: the most common seal, used for static and dynamic sealing, suitable for a variety of media and pressure conditions.

Gaskets: used for flat seals, e.g. for flange connections, where chemical and pressure resistance is required.

Seals: used for sealing of containers and equipment, such as reactors and tanks.

Diaphragms: used for sealing of pumps and valves, capable of isolating the medium and the external environment and preventing cross-contamination.

Bellows: used for sealing in high temperature and high pressure environment, such as steam and chemical pipelines.

Seals design

Hygienic design: In the pharmaceutical industry, seals need to be designed in the form of no dead space, easy to clean, no contamination, in order to comply with GMP (Good Manufacturing Practice) requirements.

Corrosion Resistant Design: Seals need to be able to resist corrosion from a variety of chemicals, including acids, alkalis, solvents, etc.

Pressure Resistant Design: Seals need to be able to maintain sealing performance under high pressure environments to prevent leakage.

Temperature resistant design: seals need to be able to maintain stable performance in high or low temperature environment.

Seals manufacturing and processing

Precision machining: Seals need to be precision machined to ensure dimensional accuracy and surface finish to ensure sealing performance.

Surface treatment: The surface of seals may require special treatment, such as polishing, coating, etc., to improve corrosion and wear resistance.

Cleaning and sterilisation: Seals in the pharmaceutical industry require stringent cleaning and sterilisation to ensure sterility and non-contamination.

Seals testing and validation

Chemical resistance test: Seals are tested for corrosion resistance in a simulated chemical environment.

Pressure Resistance Test: Test the pressure resistance of seals under simulated high pressure conditions.

Temperature resistance testing: Testing the temperature resistance of seals in simulated high or low temperature conditions.

Hygienic compliance testing: In the pharmaceutical industry, seals are required to pass hygienic compliance testing, such as USP Class VI testing.

Examples of seals applications

Chemical reactors: use chemically resistant seals such as PTFE gaskets and FKM O-rings.

Pharmaceutical equipment: use GMP-compliant seals such as silicone rubber seals and sterile diaphragms.

Piping systems: use pressure and temperature resistant seals such as EPDM gaskets and PEEK bellows.

Pumps and valves: use wear and chemical resistant seals such as NBR O-rings and PTFE diaphragms.

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